One of the main topics with increasing interest in freight transport and logistics is developing efficient and sustainable supply chain strategies that best cover customer demands and expectations as well as identify considerable cost savings and emission reductions. This study focuses on the evaluation of the potential of a logistics centre for consolidating and delivering goods at urban level, based on economic, social and environmental aspects, by performing both GIS simulation and SWOT analysis, while considering key criteria of transport management, infrastructure and fleet attributes as well as logistics and market features in the Attica region of Greece. The case refers to the largest Logistics Centre of Greece, located at Thriasio, offering door-to door services to the main industrial areas of the region. The approach followed, consists of two core elements: (1) a specific model of a last-mile delivery network in GIS environment, towards simulating and solving the vehicle routing problem (VRP) as well as b) a strategic assessment of the foreseen logistics activities through the SWOT business tool. For a transport operator with 5 vehicles, an operational distance-related cost of €1.8-1.9 per pallet was estimated. Results also show the lower environmental impact of larger vehicles due to transport pooling.